Non Oncologic Histological

Kidney cancer in adults accounts for 2% to 3% of all malignancies. Recent studies have demonstrated the prevalence of various chronic non-neoplastic morbidities in patients with renal cancer, such as hypertension and diabetes. It is not clear whether the finding of histological changes not directly related to renal cell carcinoma predicts an unfavorable evolution of renal function or even only indicates alterations secondary to these morbidities with no evident clinical significance. Aims: To evaluate the non-oncological histological findings found in the descriptions of the pieces resulting from the partial nephrectomy of patients with localized renal carcinoma; to correlate these changes with the associated chronic morbidities in these patients.

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Contrast imaging techniques

Iodinated contrast has been one of the most prescribed and used drugs in contrast imaging techniques and interventional procedures. However, some subjects may develop contrast-induced nephropathy (CIN) especially those in advanced chronic kidney disease (CKD). Diagnostic criterion is based on increasing 48h creatinine after receiving iodine. Given the fact that there is no specific treatment for CIN, prevention should be considered. Uncountable actions should be taken, including: reducing the dose, using a low-osmolar substance, avoiding dehydration and other nephrotoxic drugs. Currently, prevention has been based on using saline solution. A recent paper showed that for patients with stage 3 and 4 of CKD sodium bicarbonate did not provided greater benefit when compared to a saline solution, as well as comparing acetylcysteine to placebo. Regarding to gadolinium, besides nephrotoxicity is irrelevant, there is a risk for developing Nephrogenic Systemic Fibrosis (NSF) which may occur in those with GFR <60mL/min, particularly appears at a GFR <30mL/min. Current gadolinium use guidelines are related to patients with stage 5 (GFR <15mL/min) according to which they should undergo hemodialysis after examination.

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Role of prognostic scores

Multiple myeloma (MM) has an average survival of seven years after chemotherapy and autologous bone marrow transplantation (BMT), being a common renal dysfunction associated with an early mortality. Currently, the most used scores to assess the prognosis of MM are Durie and Salmon (DS) and International Staging System (ISS) and there are few records of the work of these scores predicting renal damage after ABMT. Aims: to evaluate the scores of prognosis ISS and DS in renal function and mortality in patients with post BMT

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